Soluble mediators derived from bronchial epithelium are able to drive Th2 differentiation in the context of rhinovirus infection
نویسندگان
چکیده
Introduction The majority of acute asthma exacerbations follow upper respiratory infections, and most are rhinovirus induced. The pathways by which a rhinovirus infection may lead to asthma development are still under scrutiny, but the role of bronchial epithelium in driving this mechanism has been considered of great importance. It has been shown that the epithelial derived cytokines IL25, IL33 and TSLP are upregulated in bronchial asthma and could be further induced by virus infection. We hypothesise that such cytokines might influence Th2 cell differentiation in the context of rhinovirus infection.
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O1 Soluble mediators derived from bronchial epithelium are able to drive Th2 differentiation in the context of rhinovirus infection Heidi Makrinioti, Ross Walton, Nikolaos Papadopoulos, Michael Edwards, Aurica Telcian, David Cousins, Kerstin Wanke, Luminita Stanciu, Mubeccel Akdis, Spyridon Megremis, Cezmi Akdis, Sebastian Johnston Airway Disease Infection Section, Imperial College London, UK; ...
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